0450. Systemic dysregulation of the angiopoietin-1/2 system in adults undergoing cardiopulmonary bypass (CBP)

Introduction Systemic capillary leak syndrome after cardiopulmonary bypass (CBP) is a well-known phenomenon, accompanied by interstitial fluid accumulation and inflammation, and can lead to end-organ failure or increased hospital length of stay (LOS). The pathophysiology responsible for capillary leak involves activation of inflammation, complement, and coagulation. The endothelium plays a central role in the activation of coagulation, and activated/dysregulated endothelium contributes to microvascular leak and enhanced adhesion of leukocytes. However, the characterization and measurement of endothelial dysregulation is not well established. Angiopoietin-1 (Ang-1) and -2 (Ang-2) are molecules implicated in angiogenesis and regulation of endothelial permeability. Their differential changes of expression could be a surrogate to quantify endothelial dysregulation after CBP.